MYOB Acumatica (formerly MYOB Advanced) vs MYOB Exo – The primary difference between MYOB Exo and MYOB Acumatica is that Exo is an on-premise ERP system whilst MYOB Acumatica is a cloud-based ERP system. In terms of their functional footprints, MYOB Exo is best suited to small-to-medium warehousing and distribution businesses and companies that require job costing, whilst MYOB Acumatica is best suited to bigger organisations with complex GL requirements and or project work.